Lu-177 supply
The state of the reactors and processors that produce the world's Lutetium-177, read from their operators, their regulators and the sector's emergency channel. Each line is our own summary of a dated primary document, with the link to the original. Nothing here is a forecast.
Supply status by region
Derived from the reactors and processors documented as suppliers of each region. Amber: a current unplanned or extended outage at a reactor or processor serving it. Red: a shortage notice from an authority or the sector's emergency channel in the last fourteen days. Never on inference.
EuropeNo disruption reported
The ANVS issues an order subject to a penalty payment to NRG PALLAS (operator of the HFR) in a news report dated September 4, 2026.
North AmericaNo news
No news from the sources in the last 60 days.
Latin AmericaNo news
No news from the sources in the last 60 days.
Africa and Asia-PacificNo disruption reported
Planned outage at OPAL (Lucas Heights) from September 14 to September 19, 2026, for refuelling and maintenance, according to ANSTO’s cycle schedule; Cycle 176 will remain online starting September 19.
Irradiation reactors
The reactors that irradiate the targets. The status comes from the last availability signal in the last 60 days, and the last signal is the most recent dated document, each with its source.
| Reactor | Power | Status | Last signal |
|---|---|---|---|
HFR Netherlands · NRG PALLAS | 45 MWt | No news | ANVS: Issues Order Subject to a Penalty Payment Against NRG PALLAS (HFR Operator) ANVS · Autoriteit Nucleaire Veiligheid en Stralingsbescherming · Sep 4, 2026 · source |
BR2 Belgium · SCK CEN | 100 MWt | No news | No signals from the sources. |
MARIA Poland · Narodowe Centrum Badań Jądrowych (NCBJ) | 30 MWt | No news | No signals from the sources. |
SAFARI-1 South Africa · Necsa | 20 MWt | No news | No signals from the sources. |
OPAL Australia · ANSTO | 20 MWt | Planned outage | OPAL: Planned outage between cycles beginning September 14 ANSTO · Calendario de ciclos de OPAL y noticias · Sep 7, 2026 · source |
MURR United States · University of Missouri Research Reactor Center | 10 MWt | No news | MURR: press release regarding the reactor or its radioisotopes MURR · Noticias (University of Missouri Research Reactor) · May 14, 2026 · source |
RA-3 Argentina · Comisión Nacional de Energía Atómica (CNEA) | 10 MWt | No news | No signals from the sources. |
IEA-R1 Brazil · IPEN/CNEN | 5 MWt | No news | No signals from the sources. |
| RA-10 Argentina · Comisión Nacional de Energía Atómica (CNEA) | 30 MWt | Under construction | The RA-10 will begin operations in 2027 using a privately funded radioisotope production model Comunicados oficiales · operadores, reguladores y gobiernos · Sep 4, 2026 · source |
| PALLAS Netherlands · NRG PALLAS | 55 MWt | Under construction | NRG PALLAS: Statement on the PALLAS Reactor NRG PALLAS · Noticias (HFR y PALLAS, Petten) · Jul 2, 2026 · source |
| RMB Brazil · Comissão Nacional de Energia Nuclear (CNEN) | 30 MWt | Under construction | No signals from the sources. |
Processors and the documented chain
Who irradiates for whom and who ships where, according to public documents. An amber node or edge means the upstream node reported a disruption.
| Processor | Isotopes | Status | Last signal |
|---|---|---|---|
| Curium Petten Netherlands · Curium | Mo-99 / Tc-99m · Lu-177 · Ir-192 | No news | No signals from the sources. |
| NTP Radioisotopes South Africa · NTP Radioisotopes SOC Ltd (Necsa) | Mo-99 / Tc-99m · I-131 · Lu-177 · Ir-192 | No news | No signals from the sources. |
| ANSTO Health (Lucas Heights) Australia · ANSTO | Mo-99 / Tc-99m · I-131 · Lu-177 | No news | No signals from the sources. |
| CNEA Ezeiza Argentina · Comisión Nacional de Energía Atómica (CNEA) | Mo-99 / Tc-99m · I-131 · Lu-177 | No news | No signals from the sources. |
| IPEN São Paulo Brazil · IPEN/CNEN | Mo-99 / Tc-99m · I-131 · Lu-177 · Ir-192 | No news | IPEN Radiopharmacy: Statement from the CNEN CNEN · Últimas notícias (IEA-R1 y radiofarmacia del IPEN) · Jun 25, 2026 · source |
| POLATOM Poland · NCBJ Radioisotope Centre POLATOM | Mo-99 / Tc-99m · I-131 · Lu-177 | No news | NCBJ: Press Release on POLATOM and Radiopharmaceuticals NCBJ · Noticias (reactor MARIA y POLATOM, Świerk) · Aug 12, 2026 · source |
Sources of the relationships
- HFR → Curium Petten · NRG PALLAS, Molybdenum-99 (targets irradiated in Petten, separation by Curium) · NRG PALLAS, NRG and Curium sign multi-year isotope production contract (HFR produces the isotopes Curium uses) · Curium, Curium extends irradiation partnership with NRG PALLAS for Lu-177 (Lu-177 production lines in Petten) · NRG PALLAS, Iridium-192 (Ir-192 production in Petten, processed into sources by Curium on the same site) · Curium, first North American manufacturer offering exclusively 100 % LEU generators (irradiation partners HFR, MARIA and BR2)
- MARIA → POLATOM · NCBJ, Iodine from Świerk for half a million patients a week (MARIA irradiation, POLATOM processing) · NCBJ, ItraPol and LutaPol awarded (Lu-177 produced in MARIA, POLATOM production line)
- SAFARI-1 → NTP Radioisotopes · Necsa, SAFARI-1 (Mo-99 feedstock for NTP Radioisotopes) · NTP Radioisotopes, SAFARI-1 (about a quarter of global Mo-99 demand, I-131 and Lu-177) · ITM, ITM and NTP manufacturing and supply agreement for n.c.a. Lu-177 (Yb-176 irradiated in SAFARI-1) · National Academies, Molybdenum-99 for Medical Imaging (2016), ch. 3 Global Production of Molybdenum-99
- OPAL → ANSTO Health (Lucas Heights) · ANSTO, Nuclear medicine facilities (OPAL target plates to the Mo-99 Manufacturing Facility; Gentech generators; Australia and the region) · ANSTO, Introduction to ANSTO 2023 (OPAL irradiation positions for Mo-99, I-131 and Lu-177; exports to the US East Coast) · National Academies, Molybdenum-99 for Medical Imaging (2016), ch. 3 Global Production of Molybdenum-99
- RA-3 → CNEA Ezeiza · CNEA, Aplicaciones del RA-3 (Mo-99, I-131, Cr-51, P-32 y Lu-177) · CNEA, Producción de radioisótopos (Centro Atómico Ezeiza; demanda nacional de Mo-99 y provisión a Brasil) · CNEA, Empezó un proceso para aumentar la producción de radioisótopos (RA-3, Centro Atómico Ezeiza)
- IEA-R1 → IPEN São Paulo · CNEN, BLOP aprova novos operadores do IEA-R1 (operação contínua para produção de I-131 e Lu-177)
- RA-10 → CNEA Ezeiza · CNEA, CNEA e INVAP inician el diseño de una planta de producción de radioisótopos de fisión (blancos del RA-10: Mo-99, I-131, Lu-177)
- PALLAS → Curium Petten · NRG PALLAS, PALLAS-reactor: securing the future of medical isotopes and cancer treatment (will replace the HFR and take over production) · Curium, Curium extends irradiation partnership with NRG PALLAS for Lu-177 (Lu-177 production lines in Petten)
- Curium Petten → Europe · OECD-NEA, The Supply of Medical Isotopes: An Economic Diagnosis and Possible Solutions (2019), tables 4.1 and 4.2 · Curium, Curium extends irradiation partnership with NRG PALLAS for Lu-177 (Lu-177 production lines in Petten)
- NTP Radioisotopes → Europe · ITM, ITM and NTP manufacturing and supply agreement for n.c.a. Lu-177 (Yb-176 irradiated in SAFARI-1)
- ANSTO Health (Lucas Heights) → Africa and Asia-Pacific · ANSTO, Nuclear medicine (Mo-99 in OPAL, Gentech generators, n.c.a. Lu-177, sodium iodide capsules; 75-80 % of isotopes used in Australia) · ANSTO, Nuclear medicine facilities (OPAL target plates to the Mo-99 Manufacturing Facility; Gentech generators; Australia and the region) · ANSTO, Introduction to ANSTO 2023 (OPAL irradiation positions for Mo-99, I-131 and Lu-177; exports to the US East Coast) · National Academies, Molybdenum-99 for Medical Imaging (2016), ch. 3 Global Production of Molybdenum-99
- MURR → North America · MURR, For first time in 30 years, critical medical radioisotope has domestic supplier (I-131; supply agreement with International Isotopes) · MURR, commercial shipments of no-carrier-added Lu-177 (weekly deliveries to Novartis; sole US producer)
Relationships documented in public sources, not contracts
Timeline
Our summary of each dated document, with the issuing body and the link. Last 180 days.
No events from the sources in this period.
Data: ANSTO · Calendario de ciclos de OPAL y noticias · Comunicados oficiales · operadores, reguladores y gobiernos · ANVS · Autoriteit Nucleaire Veiligheid en Stralingsbescherming · NCBJ · Noticias (reactor MARIA y POLATOM, Świerk) · NRG PALLAS · Noticias (HFR y PALLAS, Petten) · CNEN · Últimas notícias (IEA-R1 y radiofarmacia del IPEN) · IPEN · Notícias y comunicados oficiales (IEA-R1 y radiofarmacia) · MURR · Noticias (University of Missouri Research Reactor) · IAEA RRDB · updated on Sep 7, 2026